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KMID : 1134819970260020236
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 2 p.236 ~ p.241
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Screening and Characterization of Anticholesterogenic Substances from Edible Plant Extracts
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Park Jeong-Ro
Park Jong-Cheol
Choi Seong-Hee
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Abstract
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Inhibitory effects of several edible plant extracts against 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase, a rate-limiting enzyme in the biosynthesis of cholesterol, were screened. Inhibition rates of 10~15% were observed with hot water extracts of Allium fistulosum, Allium sativum and Cucurbita maxima. Methanol extracts of Aster scaber, Allium sativum, Zingiber officinale, Oenanthe javanica and Angelica keiskei effectively reduced the enzyme activity with inhibition rates of 29~51%. The methanol extract of Angelica keiskei was fractionated sequentially with chloroform, ethyl acetate and n-butanol. Of the fractions ethyl acetate fraction showed the highest inhibition against the enzyme. Luteolin-7-O-β-D-glucoside and hyperoside isolated from the ethyl acetate fraction of Angelica keiskei inhibited the enzyme activity by 65.5% and 14.8%, respectively, at the concentration of 30μM.
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KEYWORD
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cholesterol, HMG-CoA reductase, HMG-CoA reductase inhibitor
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